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am630 cb2 receptor antagonist  (Tocris)


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    Tocris am630 cb2 receptor antagonist
    Am630 Cb2 Receptor Antagonist, supplied by Tocris, used in various techniques. Bioz Stars score: 96/100, based on 611 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/am630+cb2+receptor+antagonist/AM+630/pm41057773-78-16-80
    Average 96 stars, based on 611 article reviews
    am630 cb2 receptor antagonist - by Bioz Stars, 2026-09
    96/100 stars

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    other:

    Article Title: Functional crosstalk between the vanilloid and endocannabinoid systems in modulating vascular tone: implications for (neuro)vascular disorder therapy.
    Article Snippet: Capsazepine TRPV1 channel antagonist 5 μM [7, 26, 37] AM6545 CB1 receptor antagonist 1 μM [38] AM630 CB2 receptor antagonist 1 μM [16, 39] CID16020046 GPR55 receptor antagonist 2.5 μM [40] Cannabidiol CB1/GPR55 receptor agonist 1 μM [41] O-1918 CBe receptor antagonist 10 μM [40, 42] AEA anandamide, ACEA arachidonyl-2’-chloroethylamide, CBe endothelial CB receptor, CB1 cannabinoid receptor type 1, CB2 cannabinoid receptor type 2, GPR55 G protein-coupled receptor 55, TRPV1 transient receptor potential vanilloid 1 2-cyclohexen-1-yl]-5-pentyl-1,3-benzenediol); and O-1918 (1,3-Dimethoxy-5-methyl-2-[(1R,6R)-3-methyl6-(1-methylethenyl)-2-cyclohexen-1-yl]benzene) (from Tocris-Bioscience, Abingdon, UK).



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    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg <t>AM630</t> + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.
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    Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 6. BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 7. Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Journal: International journal of molecular sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats.

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Figure 8. FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p< 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing

    ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: ( A ) Duration of immobility of female WKY rats ( B ) duration of swimming (mean + SEM) of female WKY rats. Rats received either vehicle (n = 13) or 5 mg/kg CBDA-ME (n = 13), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 12), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 12), 30 mg/kg Imipramine (n = 12). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: BDNF blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 7) or 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 7), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 7). * p < 0.05.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: Selected endocannabinoids blood level (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05; ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques:

    FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Journal: International Journal of Molecular Sciences

    Article Title: Cannabinoid Receptor 2 Blockade Prevents Anti-Depressive-like Effect of Cannabidiol Acid Methyl Ester in Female WKY Rats

    doi: 10.3390/ijms24043828

    Figure Lengend Snippet: FAAH expression in the hippocampus (mean + SEM) of female WKY rats. Rats received either vehicle (n = 4) or 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM251 + 5 mg/kg CBDA-ME (n = 5), 1 mg/kg AM630 + 5 mg/kg CBDA-ME (n = 5). * p < 0.05, ** p < 0.01.

    Article Snippet: Experiment 2: A selective CB1 receptor antagonist AM251 (1-(2,4-dichlorophenyl)-5-(4-methoxyphenyl)- 4-methyl-N-(1-piperidinyl)-1H pyrazole-3 carboxamide; Tocris Bioscience, UK) and a selective CB2 receptor antagonist AM630 (6-Iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl](4methoxyphenyl) methanone; Tocris, Bristol, UK) were initially dissolved in dimethyl sulphoxide (DMSO; SIGMA, St. Louis, MO, USA) and then diluted with 0.9% saline using TWEEN 80 (SIGMA, St. Louis, MO, USA).

    Techniques: Expressing